Tuesday, April 16, 2013

Endocannabinoids And Cancer - NIH Publication

I came across this from the NIH this morning.
The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid receptors. Although the primary focus of endocannabinoid biology has been on neurological and psychiatric effects, recent work has revealed several important interactions between the endocannabinoid system and cancer. Several different types of cancer have abnormal regulation of the endocannabinoid system that contributes to cancer progression and correlates to clinical outcomes. Modulation of the endocannabinoid system by pharmacological agents in various cancer types reveals that it can mediate antiproliferative and apoptotic effects by both cannabinoid receptor-dependent and -independent pathways. Selective agonists and antagonists of the cannabinoid receptors, inhibitors of endocannabinoid hydrolysis, and cannabinoid analogs have been utilized to probe the pathways involved in the effects of the endocannabinoid system on cancer cell apoptosis, proliferation, migration, adhesion, and invasion. The antiproliferative and apoptotic effects produced by some of these pharmacological probes reveal that the endocannabinoid system is a promising new target for the development of novel chemotherapeutics to treat cancer.
Whew. Well that is going to require a translation. The short version - cannabinoids that increase or decrease activity of the cannabinoid receptors can cure cancer. They do this by preventing cancer cells from dividing, from moving around in the body (metastasis), from adhering to body tissue, and a number of other things cancer cells do in the body.

Obviously a look at chemotherapeutics is in order. Here is a video narrated by Peter Coyote (a friend in a different life over 40 years ago) posted here previously but I'm doing it again because it fits:
What if Cannabis Cures Cancer?


Cannabis Cures Cancer! Rick Simpson: Run From The Cure

Here is Rick Simpson's site Phoenix Tears.

Things have come a ways since Rick made the video in 2008. We now know that different ratios of he different cannabinoids in the cannabis plant have different effects. Some enhance receptor operation some suppress it. Thus different strains of cannabis will have varying efficacy depending on what you want to use it for. I go into that some at: CBD Science - HPLC Analysis.

This may also be helpful: Endocannabinoids - The Science. The endocannabinoid system is a major regulator in the body implicated in almost all diseases including cancer.

How To Make Cannabis Oil

Medical Marijuana prohibition is a crime against humanity and a violation of the religious precept - heal the sick.

Pass it on.

Update: Spanish study confirms cannabis oil cures cancer. Lots of text and video. Plus good comments. You can find papers by Dr. Manuel Guzman at this NIH link.

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